Pediatrics in Review
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(Pediatrics in Review. 2008;29:142-143.)
© 2008 American Academy of Pediatrics

In Brief

Wilms Tumor

The first 20% of the full text of this article appears below.

An X Chromosome Gene, WTX, Is Commonly Inactivated in Wilms Tumor. Rivera MN, Kim WJ, Wells J, et al. Science. 2007;315 :642 –645[Abstract/Free Full Text] Current Therapy for Wilms Tumor. Metzger ML, Dome JS. Oncogene. 2005;10 :815 –826 Renal Tumors. Dome JS, Perlman EJ, Ritchey ML, Coppes MJ, Kalapurakal J, Grundy PE. In: Pizzo PA, Poplack DG, eds. Principles and Practice of Pediatric Oncology. 5th ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2006:905 –932

In 1899, surgeon Max Wilms published a report of seven children suffering from malignant tumors arising from renal parenchyma. Nephroblastoma now is recognized as the most common malignant renal tumor of childhood and is known more commonly as Wilms tumor. From 1975 to 1995, Wilms tumor was estimated to account for 6% of childhood cancers in the United States, with an approximate annual incidence of 500 cases. The incidence is slightly higher in females, with a male-to-female ratio of 0.92:1.00 for unilateral disease and 0.60:1.00 for bilateral disease.

Most children who have Wilms tumor are brought to their doctors when a parent or caregiver notices an abdominal . . . [Full Text of this Article]


Gregory J. Aune, MD, PhD
 Johns Hopkins Hospital
Baltimore, MD

Janet R. Serwint, MD, Consulting Editor




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